Metabolic activation

Application of Metabolic Activation System in Human Cell Transformation Model

代谢活化系统在人细胞转化模型中的应用

The study on new in vitro metabolic activation system in gamete mutation test

人精子诱变检测中新体外代谢活化系统的研究

Gene Toxicity of Pollutants by Utilizing the Chemical Model of Metabolic Activation System

利用模拟代谢活化体系研究污染物的基因毒性

Study of the False Positive Response and the Metabolic Activation System S _9 Mix in SOS Chromotest

SOS显色法中的假阳性及代谢活化系统S9混合物的研究

However , the relation between fetal GC metabolic activation and peripheral metabolic programming has not been reported yet .

有关胎儿时期GC活化代谢与外周组织代谢编程之间的关系尚未见明确报道。

In vitro test , determinations of the DNA damage induced by AA and its metabolic activation were performed .

利用体外试验研究AA所致DNA损伤及其代谢活化作用。

Due to the permeability of yeast cells and its simpler metabolic activation system , this system has been compromised for practical applications .

但由于酵母细胞的通透性问题，以及过于简单的代谢活化系统，阻碍了该检测系统的实际应用。

Effects of Genetic Variations of Human Cytochrome P450 Oxidoreductase on the Metabolic Activation of Anticancer Prodrugs and Environmental Toxins

人细胞色素P450氧化还原酶基因多态性对抗癌药物及环境毒物活化的影响研究

The results showed that the water organic pollution in the Xihe River had got mutagenicity of frameshift and base substitution without metabolic activation .

结果表明：20-30ml（每皿）细河水所含有机污染物，毋需经过代谢活化，即可引起移码型和碱基置挨型的致突变作用。

To probe the DNA cross-links induced by AA and its metabolic activation in calf thymus DNA , EB fluorescence assay was used .

以EB荧光法研究AA致牛胸腺DNA交联作用及其代谢活化。

The metabolic activation in mammalian was needed for the genotoxicity / carcinogenicity of DCNPA ;

DCNPA的遗传毒作用／致癌作用需要哺乳动物体内活化；

Cytochrome P450 ( CYP ) - catalyzed metabolic activation is required for AFB1 to exert its carcinogenicity .

AFB1需要经过细胞色素P450（CYP）的代谢活化才具有致癌性。

Combining with our previous studies , it suggests that a essential metabolic activation pathway of the herbicide could be reduction of 6 nitro to carcinogenic amine .

结合前期研究结果推断，6位硝基还原成胺基是该除草剂在体内活化致癌的基本途径。

The aromatic amine 2-acetylaminofluorene ( AAF or 2-AAF ) is a model chemical to study those mutagens and carcinogens which require metabolic activation for the mechanism of mutagenesis and carcinogenesis .

芳香胺类化合物2&乙酰氨基芴（2-acetylaminofluorene，2-AAF或AAF）是一种研究致突变剂和致癌物代谢活化的工具药，广泛运用于致突变致癌机制研究中。

Background and objectBenzo [ a ] pyrene ( B [ a ] P ) is a ubiquitous environmental pollutant which is a indirect carcinogen requires metabolic activation , generated from cigarette smoke and coal combustion .

背景与目的苯并（a）芘（Benzo[a]pyrene，B[a]P）是一种常见的环境污染物，广泛存在于燃煤和吸烟过程中，是一种间接致癌物。

The change of expressions of fetal hippocampal 11 β - HSD-1 and 11 β - HSD-2 induced variation of local GC metabolic activation , which probably indirectly influences the normal development of fetal HPA via affecting hippocampal function .

胎海马11β-HSD-1和11β-HSD-2表达改变所致局部GC代谢活化变化，将可能通过影响海马功能而间接影响胎儿HPA的正常发育。

Conclusion Cytotoxicity of TCE to normal lymphocytes and proliferation of sensitized lymphocytes were enhanced by metabolic activation . The metabolites of TCE may act as effective immune hapten to stimulate the proliferation of hapten-specific lymphocytes in TCE-sensitized animals .

结论TCE经代谢活化后对正常淋巴细胞的毒性增强，促进致敏淋巴细胞的增殖活性，TCE的代谢产物可能作为半抗原诱导了抗原特异性淋巴细胞的增殖转化。

Methods Ames test was conducted with rat liver S9 metabolic activation system ( S9-mix ) induced by Compound Danshen Dripping Pills at different doses , and the amounts of reverse mutation induced by 2-AAF were compared between groups with different S9-mix .

方法将复方丹参滴丸不同剂量诱导处理后的大鼠肝S9作为代谢活化系统进行Ames试验，比较加入S9前后2AAF对鼠伤寒沙门氏菌的回复突变率。

Methods : L5178Y mouse lymphoma cells were exposed to genistein at concentrations 5,10,15 and 20 μ g / ml for 3 hours without S9 metabolic activation . Determination of cytotoxicity , plating efficiency and mutant frequency were performed by using the microwell method .

方法：不加S9活化的条件下，用染料木素5、10、15、20μg/ml处理L5178Y细胞3h，采用微孔板法进行细胞毒性、平板接种效率和突变频率测定。

Cytochrome P450 ( CYP ) is one of the most important representatives of drug metabolism enzymes , and plays a key role in the metabolic inactivation / activation of numerous exogenous and endogenous . CYP exists mainly in liver microsomes .

细胞色素P450（CytochromeP450，CYP）是参与众多外源物和内源物在体内代谢失活/活化的重要酶系，主要存在于肝微粒体中。